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Toye AA, Lippiat JD, Proks P, Shimomura K, Bentley L, Hugill A, Mijat V, Goldsworthy M, Moir L, Haynes A, Quarterman J, Freeman HC, Ashcroft FM, Cox RD (2005) A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice

Treating them as equivalent is a critical error in research design

This process causes lactate accumulation and promotes the inflammatory behavior of immune cells (69, 70)

Nrf2 not only increases the enzyme levels of both the oxidative and non-oxidative arms, but it also facilitates the utilization of ribose 5-phosphate for the purine nucleotide synthesis (Mitsuishi et al., 2012), which appears to maintain the ribose 5-phosphate concentration at a low level and efficiently divert glucose flux into purine nucleotide synthesis through both arms of the pentose phosphate pathway

Every cell produces it, and it plays a central role in protecting tissues from oxidative stress the kind of daily damage caused by UV exposure, pollution, poor sleep, and processed food